Reward and autoreceptors

Presynaptic autoreceptors Maurizio Raiteri

Presynaptic axon terminals of all known neuronal families possess on their external membrane release-regulating receptors sensitive to the neuron's own transmitter and which have been termed autoreceptors (Starke et al. 1989). Autoreceptors coexist with release-regulating heteroreceptors, which are activated by transmitters/modulators other than the neuron's own transmitter (Vizi and Kiss 1998)...

Single Electroconvulsive Shock and Dopamine Autoreceptors

Dopamine (DA) auto receptor down regulation has been suggested to mediate the therapeutic effect of antidepressant treatments including electroconvulsive therapy (ECT). Suggestion has also been made that a single ECT may have antidepressant potential via such a mechanism. The present study was therefore conducted to assess the effects ill a single electroconvulsive shock (ECS) on dopamine auto ...

Asymptotic Behavior of Multivariate Reward Processes with Nonlinear Reward Functions

COVARIANCE MATRIX OF MULTIVARIATE REWARD PROCESSES WITH NONLINEAR REWARD FUNCTIONS

Multivariate reward processes with reward functions of constant rates, defined on a semi-Markov process, first were studied by Masuda and Sumita, 1991. Reward processes with nonlinear reward functions were introduced in Soltani, 1996. In this work we study a multivariate process , , where are reward processes with nonlinear reward functions respectively. The Laplace transform of the covar...

Hippocampal nicotinic autoreceptors modulate acetylcholine release.

Introduction Nicotine promotes transmitter release in the brain by a direct action on presynaptic terminals. Pharmacological evidence confirms that this action is mediated by nicotinic acetylcholine receptors (nAChR). The most abundant brain nAChR, the a4B2 subtype, is identified by the binding of tritiated nicotine ([,H]Nic) [ 13. Lesioning and subcellular fractionation studies suggest that th...